• br Materials and methods br Results br Discussion

  2021-07-19

  

  Materials and methods Results Discussion COX-2-mediated production of PGE2 is involved in cell growth and metastasis of many cancers. Previous studies indicated that COX-2 was overexpressed in many cancer tissues and that PGE2 increased cancer cell growth, a process that could be suppressed

• br Conflict of interest statement br References and

  2021-07-19

  

  Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We acknowledge financial support by the Swiss State Secretariat for Education, Research and Innovation (Federal

• Acknowledgments br Introduction Diabetes mellitus

  2021-07-19

  

  Acknowledgments Introduction Diabetes mellitus (DM) is a multifactorial disease [1] associated with serious comorbidities. This condition has recently reached epidemic proportions, as its occurrence has exponentially increased in the general population. Over 400 million people worldwide were est

• There are numerous theories of schizophrenia etiopathology a

  2021-07-19

  

  There are numerous theories of schizophrenia etiopathology and genetics is often taken into consideration [25]. The dopamine D2 receptor is important since it is blocked by typical antipsychotic drugs with high affinity which is correlated with the ability to control psychotic symptoms in schizophre

• methylergometrine br Materials and methods br Results br

  2021-07-19

  

  Materials and methods Results Discussion Although autophagy is known to be implicated in the therapeutic effect of DNA alkylating agents such as MNNG [28], [29], [30], the molecular mechanisms underlying autophagy induced by MNNG remain largely elusive. In this study, we present evidence sh

• Previous studies reported that combined administration of

  2021-07-19

  

  Previous studies reported that combined administration of licorice/GL and TWHF/TP showed reduced toxicity and equal or even potentiated therapeutic efficacy when treating arthritis (YS et al., 2006, YS et al., 2008, Zhang et al., 2007). Our findings that GL reduced exposure to TP in rats confirmed t

• The consistent anti anxiety effects obtained with intra mPFC

  2021-07-19

  

  The consistent anti-anxiety effects obtained with intra-mPFC injections of CP 376395 strongly suggest a tonic role of CRF at CRF1 receptors located within this limbic TCS 359 area in the modulation of anxiety in the mouse on the EPM. Intra-mPFC injection of CP 376395 led mice to explore the potenti

• Moreover as shown in Fig f while the knockdown of

  2021-07-19

  

  Moreover, as shown in Fig. 5f, while the knockdown of SMURF2 in wild-type Doxorubicin has no significant effect on HSP27, in CK2α/α′(−/−) cells it leads to an increase of HSP27 level. These results suggest that SMURF2 affects HSP27 protein stability only when overexpressed, at least in our cell mod

• The repeat sequence TTAGGG of telomere

  2021-07-19

  

  The repeat sequence “TTAGGG” of telomere could be directly recognized by TERF1. TERF1 is indispensable for the maintenance of telomere Fluorouracil structure and integrity (Tan et al., 2017). Trf1 genetic depletion in vivo induces a persistent DNA damage response and telomere uncapping, which effec

• br Materials and methods br Results br Discussion Inflammato

  2021-07-19

  

  Materials and methods Results Discussion Inflammatory signalling and in particular the arachidonic Chlorprothixene cascade have been suggested as targets for disease modification, optimization of the therapeutic response, and even restoration of pharmacosensitivity (Potschka, 2010). Recent

• br Materials and methods Details on materials and methods ca

  2021-07-17

  

  Materials and methods Details on materials and methods can be found in the Supplemental material section. Results Discussion In our experiments we mimicked inflammation by LPS challenge of M0 macrophages. We discovered a strong increase in expression of CH25H and CYP7B1 while CYP27A1 and H

• CJ-42794 Mutation in BRCT II domain W R either

  2021-07-17

  

  Mutation in BRCT-II domain (W893R) either in the full-length context or the C-terminal context greatly reduced the expression of LIG4 (Fig. 2B, Fig. 3B), suggesting the importance of BRCT-II domain in the maintenance of LIG4. In this regard, it might be noted that LIG4 protein was undetectable in Li

• Diacylglycerol kinase was one of the hits

  2021-07-17

  

  Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a SCF, murine recombinant protein of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns and functions [61

• Moreover maintaining the pyrimidine pool is not the only

  2021-07-17

  

  Moreover, maintaining the pyrimidine pool is not the only important role played by DHODHs. In Toxoplasma gondii, for instance, DHODH plays a second essential function [38] possibly coupled to the mitochondrial respiratory activity, where it replenishes ubiquinol levels and prevents reactive oxygen s

• br Results br Discussion The sequence homology based cluster

  2021-07-17

  

  Results Discussion The sequence homology-based clustering of the human kinome by Manning et al. (2002) has been extremely useful to organize kinases into hepititis b by sequence relationship. Since kinases are such prominent drug targets, we expect that clustering of the kinases by their inhi

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